Only in Norman times (1150-1167) there were the first fortifications and feudal lords. During the 14th century the feud passed to the Acquaviva and later to the Scorrano. In 1548 Cermignano, along with Montegualtieri, became a fief of De Sterlich family who in 1548 were appointed by the king Marquis of Cermignano.

It rises on a hill which dominates the southern Vomano valley of the ancient territory of the Adriatic Sabines and later Roman colony of Hatria.